General access to aminobenzyl-o-carboranes, a new class of carborane derivatives. Entry to enantiopure carborane-amine combinations


Author/s: V. Terrasson, J. G. Planas, D. Prim, F. Teixidor, C. ViƱas, M. E. Light and M. B. Hursthouse
Reference: Chemistry – A European Journal, 2009, 15, 12030-12042.


The synthesis of new aminobenzyl-o-carboranes in a practical three-step procedure is described. The strategy involved the preparation of o-carboranylmethanols followed by chlorination and nucleophilic amination. The expected amines were obtained in good overall yields. The synthetic pathway was also extended to the synthesis of new enantiopure carborane-amine combinations.

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