Cobaltabisdicarbollide anion receptor for enantiomer-selective membrane electrodes


Author/s: A. I. Stoica, C. ViƱas and F. Teixidor
Reference: Chemical Communications, 2009, 4988-4990.


A potentiometric sensor for enantiomers has been prepared with no chiral additives, only cobaltabisdicarbollide and the protonated enantiomer. Most bio-molecules are optically active, therefore their interaction with optically active drugs may be different depending on the enantiomer. One of the enantiomers can exhibit biological activity, whereas the other could show no activity, and even toxicity or antagonist effects.1 In the last few years, a great interest in the separation and determination of optically active compounds has arisen.

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